Driving CARs on the uneven road of antigen heterogeneity in solid tumors
نویسندگان
چکیده
منابع مشابه
Mesothelin-Targeted CARs: Driving T Cells to Solid Tumors.
UNLABELLED Chimeric antigen receptors (CAR) are synthetic receptors that target T cells to cell-surface antigens and augment T-cell function and persistence. Mesothelin is a cell-surface antigen implicated in tumor invasion, which is highly expressed in mesothelioma and lung, pancreas, breast, ovarian, and other cancers. Its low-level expression in mesothelia, however, commands thoughtful thera...
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ژورنال
عنوان ژورنال: Current Opinion in Immunology
سال: 2018
ISSN: 0952-7915
DOI: 10.1016/j.coi.2018.03.002